FIELD: medicine. SUBSTANCE: cryoprecipitated plasma fraction preliminary purified on aluminium hydroxide is purified twice successively by ion-exchange chromatography on the resin of macroporous vinyl polymer type that contains diethylaminoethyl groups. Then additional purification is carried out by affinity chromatography on column with gelatin-Sepharose equilibrated with buffer solution that is used as eluent on the preliminary stage. EFFECT: increased specific activity and multimers content of high molecular mass. 3 cl
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