FIELD: medicine, pharmaceutics.
SUBSTANCE: declared invention refers to chemical-pharmaceutical industry. A method involves the following stages: preparing a solution of von Willebrand factor or von Willebrand factor/factor VIII complex which contains VWF in concentration up to 12 IU VWF:RCoAui and has the von Willebrand factor/factor VIII ratio equal to 0.4 or more; nanofiltering through a filter of pore size less than 35 nanometres at pressure less than or equal to 0.5 bar and in the presence of 0.05 to 0.2 M of calcium ions.
EFFECT: development of the effective method for producing concentrated von Willebrand factor or factor VIII/von Willebrand factor complex to be applied for treating hemophilia And or von Willebrand disease.
11 cl, 8 ex, 6 tbl, 1 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| MODIFIED VON WILLEBRAND FACTOR WITH PROLONGED HALF-CYCLE IN VIVO, USING IT AND METHODS FOR PREPARING | 2009 |
|
RU2528855C2 |
| PREPARATION CONTAINING VIII FACTOR AND VON WILLEBRAND FACTOR PEPTIDES | 2015 |
|
RU2714154C2 |
| VON WILLEBRAND FACTOR OR FACTOR VIII AND VON WILLEBRAND FACTOR FOR TREATMENT OF COAGULOPATHY, INDUCED BY PLATELET INHIBITORS | 2009 |
|
RU2563236C2 |
| PREPARATIONS CONTAINING VON WILLEBRAND FACTOR (vWF) AND METHODS, KITS AND APPLICATIONS RELATED TO THEM | 2010 |
|
RU2579977C2 |
| COMPOSITIONS AND METHODS OF TREATMENT OF COMPLICATIONS AND DISORDERS ASSOCIATED WITH THE VON WILLEBRAND FACTOR | 2018 |
|
RU2806844C2 |
| METHOD OF PURIFYING COAGULATION FACTOR VIII | 2009 |
|
RU2698392C2 |
| METHOD FOR PREVENTION OF HEMORRHAGIC COMPLICATIONS IN PATIENTS WITH VON WILLEBRAND DISEASE DURING IN VITRO FERTILIZATION | 2023 |
|
RU2816883C1 |
| METHOD FOR PURIFICATION OF BLOOD-COAGULATION FACTOR VIII | 2009 |
|
RU2567811C2 |
| METHOD OF SEPARATING VIII FACTOR FROM BLOOD PRODUCTS | 2017 |
|
RU2734783C2 |
| METHOD OF PREPARING OF CONCENTRATE OF FACTOR VIII AND VON VILLEBRAND FACTOR | 1990 |
|
RU2025129C1 |
