FIELD: biotechnology.
SUBSTANCE: disclosed is a method for reducing the level of at least one protein selected from a group consisting of plasminogen and tissue plasminogen activator in a solution containing fibrinogen. Method comprises passing human cryoprecipitate plasma containing fibrinogen through a resin for hydrophobic chromatography with charge induction in conditions, in which plasminogen and the tissue plasminogen activator binds to the resin, and recovering a cryoprecipitate solution containing fibrinogen which passes through the resin. Resin for hydrophobic chromatography with induction of molar charge is HEA or PPA resin.
EFFECT: concentration of at least one protein selected from a group consisting of plasminogen and tissue plasminogen activator in the solution is reduced by at least 50 % compared to the initial substance.
18 cl, 8 dwg, 6 tbl, 10 ex
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