NITROGLYCEROL AQUEOUS SOLUTION FOR INFUSION AND A METHOD OF ITS PREPARING Russian patent published in 1997 - IPC

FIELD: medicine, pharmacy. SUBSTANCE: an aqueous solution of nitroglycerol for infusions has, wt.-%: nitroglycerol substance with glucose at their mass ratio = 1:(8-10) 0.95-1.09; sodium chloride, 0.51-0.65; potassium dihydrogen phosphate, 0.05-0.056, and water for injection - the balance. Method involves preparing nitroglycerol substance with glucose by stirring a mixture glucose-ethyl acetate at ratio of components 2:1 mas./vol. and 14-20% solution of nitroglycerol in ethyl acetate at mass ratio of nitroglycerol : glucose = 1:(8-10) for 1-2 h. Ethyl acetate is removed at 40-50 C, substance is dissolved in water by stirring at Reinolds number above 25000 at 20-30 C followed by addition of sodium chloride and potassium dihydrogen phosphate. Solution is used in cardiology. EFFECT: improved method of preparing. 2 cl, 3 tbl