1,2,4-TRIAZOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITION AND INTERMEDIATE COMPOUNDS Russian patent published in 1997 - IPC

FIELD: organic chemistry. SUBSTANCE: product: derivatives of 1,2,4-triazole of the formula: where: R - phenyl substituted with 1-2 halides; R¹ - C_1-4-alkyl; R² - hydrogen or C_1-4-alkyl; Het - pyridinyl, pyridazinyl, pyrimidinyl or pyrazinyl as free or substituted with C_1-4-alkyl, C_1-4-alkoxy, halide, cyano-group, amine or -NHCO₂-(C_1-4), or their pharmaceutically acceptable salts. Invention relates to also pharmaceutical composition based on thereof and intermediate compounds for synthesis of derivatives of 1,2,4-triazole of the general formulas: -alkyl where: R¹, R² and R - as indicated above; Het¹ - pyridinyl, pyridazinyl, pyrimidinyl or pyrazinyl possibly substituted with C_1-4-alkyl, C_1-4-alkoxy, halide, cyano- or nitro-group; Y - group to be removed. Synthesized compounds were used as antifungicide preparations that can be used for treatment of human and animals with fungal diseases. EFFECT: improved method of synthesis. 19 cl, 3 tbl