METHOD OF SYNTHESIS OF TRIAZOLES, ULTIMATE AND INTERMEDIATE COMPOUNDS OF METHOD Russian patent published in 2000 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention describes method of synthesis of triazoles of the formula (I) or its additive acid or base salt where R means phenyl optionally substituted with 1-3 substituents being each is taken among halogen atom and trifluoromethyl-group; R¹ means C₁-C₆-alkyl; "Het" is pyrimidinyl optionally substituted with 1-3 substituents being each is taken independently among C₁-C₄-alkyl, C₁-C₄-alkoxy-group, halogen atom, oxo-group, benzyl and benzylhydroxy-group. Method involves addition reaction of compound of the formula (II) where R is determined early for compound of the formula (I) with compound of the formula (III) where R¹ and "Het" are determined early for compound of the formula (I) and X means chlorine, bromine or iodine atom in the presence of zinc, iodine and/or Lewis acid and aprotonic organic solvent followed by optional conversion of compound of the formula (I) to its additive acid or base salt. Invention describes also ultimate and intermediate compounds of the method. EFFECT: increased yield of end product, enhanced stereoselectivity. 39 cl, 10 ex