DERIVATIVES OF PYRROLO[2,3-D]PYRIMIDINES, PHARMACEUTICAL COMPOSITION, PYRROLO[2,3-D]PYRIMIDINES, DERIVATIVES OF PYRROLE Russian patent published in 1998 - IPC

FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: invention relates to derivatives of pyrrolo[2,3-d] pyrimidines of the formula (I) where B - group ; R₁ - H, alkyl possibly substituted with hydroxy-group, alkoxyl, N-((C_1-2-alkyl)- -((C_1-4-alkyl)-group; R₂ - alkyl, C_3-8-cycloalkyl, ((C_1-6-alkylene)-C_3-8-cycloalkyl, C_1-10-alkylenephenyl optionally substituted with alkyl in phenyl ring; R₃, R₄ and R₆ - hydrogen or alkyl; R₅ - phenyl substituted with 1-3 substituents taken from fluorine, chlorine, bromine, alkyl, alkoxy, trifluoromethyl or a single OH, J, NH₂, NH-alkyl, COO-alkyl, formyl where alkyl can be substituted with fluorine, chlorine atoms, hydroxy-, alkoxy-group or to have a single double bond; R₁₁ - H, F, chlorine, CO-((C_1-2-alkyl), COO-((C_1-2-alkyl); R₁₂ - H or C_1-4-alkyl, or their pharmaceutically acceptable salts showing antagonistic activity with respect to corticotropin releasing factor. EFFECT: improved method of synthesis, enhanced activity of compounds. 13 cl, 22 tbl, 38 ex