CYCLIC PEPTIDES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITION Russian patent published in 1997 - IPC

FIELD: chemistry of peptides. SUBSTANCE: product: cyclic peptides of the general formula (I) given in description text, or their pharmaceutically acceptable salts where: R₁ - hydrogen, (C₁-C₄)-alkyl, phenyl, benzyl; R₂ - hydrogen, lower alkyl; R₁₀ - hydrogen, halogen; n = 1; n′ = 0; j - D-Ala, D-Val, D-Ile, D-Leu, D-Nle, D-phenyl-Gly, D-Phe, D-Lys, D-Orn, D-Met, D-Pro; β - Ala, D-Tyr, D-Ser, NMeGly, D-cyclohexyl-Gly, D-cyclohexylmethyl-Gly, D-Norvaline, D-2-aminobutyric acid, D-2-aminopentanoic acid-Gly, N^ε-p-azidobenzoyl-D-Lys, N^ε-p-benzoylbenzoyl-D-Lys, N^ε-p-acetobenzoyl-D-Lys, Ν^ε-dansyl-D-Lys, N^ε-t-butoxylcarbonylglycyl-D-Lys, N^ε-glycyl-D-Lys, N^ε-p-benzoylbenzoylglycyl-D-Lys, N^ε-p-phenylbenzoyl-D-Lys, N^ε-m-benzoylbenzoyl-D-Lys or N^ε-o-benzoylbenzoyl-D-Lys; k - α-NMeArg, N^δ, N^α-dimethyl-N^δ-guanidinyl-Orn, N^α-MeLys or N^ε, N^α-di-MeLys; L - Gly; M - Asp, β-MeAsp or NMeAsp, and pharmaceutical composition inhibiting platelet effect and containing effective amount of cyclic peptide of the formula (I) as an active component. Synthesized peptides show antithrombic activity. EFFECT: enhanced effectiveness. 8 cl, 8 tbl