CYCLOPEPTIDES, A METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEIR AND A METHOD OF THEIR PREPARING Russian patent published in 1999 - IPC

FIELD: chemistry of peptides, pharmacy. SUBSTANCE: invention relates to new cyclopeptides of the formula (I): cyclo-(Arg-B-Asp-X-Y) where B, X and Y have values indicated in p. 1 of the invention claims and to their salts also. These compounds act as integrin inhibitors and can be used for prophylaxis and treatment of patients with circulation diseases and in tumor therapy especially. Method of synthesis of compounds of the formula (I) involves cyclization of the corresponding linear peptide or reactive derivative of such peptide by treatment with a cyclizing agent followed by if necessary interaction with acid or base that results to salt formation. Invention describes a method of preparing a pharmaceutical composition and a pharmaceutical composition containing compounds of the formula (I) - an antagonist of and α∨β₃--integrins. EFFECT: inhibitory properties of compounds with respect to integrins. 7 cl, 5 ex