PROCESS FOR PREPARING PHENYLKYLAMINES OR SALTS OF THESE COMPOUNDS Russian patent published in 1994 - IPC

FIELD: organic chemistry. SUBSTANCE: the product: phenylalkylamines of the general formula: C₆H₅CH₂CH(R₁)NH(R₂) (1) wherein R₁ is straight or branched C₂-C₈-alkyl, C₇-C₁₀-phenylalkyl, C₃-C₈-cycloalkyl, phenyl; R₂ is C₁-C₈-alkyl, C₁-C₈- alkyl substituted with a halogen atom, hydroxy or alkoxy containing from 1 to 4 carbon atoms; alkyl containing 3 carbon atoms and substituted with phenyl; C₃-C₈ cycloalkyl provided that R₁ and R₂ together contain at least 5 carbon atoms, and in the case when is ethyl; R₁ cannot be isobutyl, or salts of these compounds. Reagent 1: an amine of the general formula: R₂ (2) wherein C₆H₅CH₂CH(R₁)NH₂ is as defined above. Reagent 2: R₁ (3) wherein X is halogen, a sulfonic acid ester residue; XCH(R₃)R₄ is hydrogen, R₃-alkyl, C₁-C₇-alkyl substituted with a halogen atom, hydroxy or alkyl containing from 1 to 4 carbon atoms, alkyl containing 2 carbon atoms substituted with phenyl; C₁-C₇ is hydrogen or R₄ and R₃ and R₄ are alkyl provided that they together contain not more than 5 carbon atoms or R₃-R₄ together with CH can form a cycloalkyl ring containing from 3 to 8 carbon atoms. Reaction conditions: in the presence of an acid binding agent such as an excess amount of an amine, an organic or inorganic base or an alkaline ion exchanger followed, if necessary, by conversion of the compound of the formula (1) into a salt. EFFECT: improved properties of the resulting compounds. 7 tbl