4-METHOXYALKYL-2-TERT-BUTYLPHENOLS AS INTERMEDIATE COMPOUNDS FOR SYNTHESIS OF METOPROLOL AND ITS ANALOGS Russian patent published in 1997 - IPC

Abstract RU 2100341 C1

FIELD: organic chemistry. SUBSTANCE: 4-methoxy-2-tert.-butylphenols (I) (alkyl: ethyl- propyl-) were synthesized by treatment of 4-chloroalkyl-2,6-di-tert.-butylphenols with sodium methylate (or sodium hydroxide solution in methanol) at heating followed by thermolysis of the formed 4-methoxyalkyl-2,6-di-tert. -butylphenols at 280-290 C. Method provides synthesis of metoprolol analogs. EFFECT: improved technology, enhanced purity of intermediate compounds and metoprolol.

Similar patents RU2100341C1

Title	Year	Author	Number
PROCESS FOR RECOVERY OF DICYCLOPENTADIENE	1994	Krysin A.P. Egorova T.G. Kobrin V.S.	RU2063395C1
METHOD OF SYNTHESIS OF 2,6-DI-TERT-BUTYL-4-(3-HYDROXYPROPYL)-PHENOL	1990	Krysin A.P. Khalikova N.U.	SU1814807A3
METHOD OF SYNTHESIS OF MERCAPTANES COMPRISING STERIC HINDRANCE PHENOL FRAGMENTS	2000	Krysin A.P. Mashkina A.V. Knjazev V.V.	RU2184727C2
METHOD FOR PREPARING PHOTO- AND THERMOSTABILIZER OF WEATHERPROOF POLYETHYLENE	2004	Krysin A.P. Vasil'Ev V.G. Rusov Vladimir Pavlovich Aleksandrova Tamara Ivanovna Koretskaja Ljudmila Sergeevna Egorova T.G. Grazhdannikov A.E.	RU2265008C2
BIS-[3-(3,5- DIMETHYL-4-HYDROXYPHENYL) -PROPYL-1]- SULFIDE AS A THERMOSTABILIZER SEVILEN AND 3-(3,5- DIMETHYL-4- HYDROXYPHENYL) -PROPANOL-1 AS AN INTERMEDIATE PRODUCT IN SYNTHESIS OF BIS-[3-(3,5- DIMETHYL-4- HYDROXYPHENYL) -PROPYL-1]-SULFIDE - A THERMOSTABILIZER SEVILEN	1991	Khalikova N.U. Krysin A.P. Demidova V.M. Zaveleva I.G. Lugova L.I.	SU1833606A3
METHOD OF SYNTHESIS CHLOROAZINES CONTAINING O-HYDROXYPHENYL GROUP	1991	Krivopalov V.P. Nikolaenkova E.B. Mamaev V.P.	RU2026295C1
DI-3-(3,5-DI-TERT-BUTYL-4-HYDROXYPHNYL)-2-HYDROXY-1-(N ISOPOPYLAMINO)PROPANE SUCCINATE WITH ANTIARRHYTMIC ACTIVITY	2008	Krysin Aleksej Petrovich Tolstikova Tat'Jana Genrikhovna Bryzgalov Arkadij Olegovich Shul'Ts Ehl'Vira Ehduardovna Shakirov Makhmut Minakhmetovich	RU2396248C1
PROCESS FOR PREPARING ALKYL ETHERS OF O-OR P- NITROPHENOLS	1993	Malykhin E.V. Vasilevskaja T.N. Shtejngarts V.D.	RU2084444C1
METHOD OF PRODUCING HIGH-PURITY 4-(2-HYDROXYETHYL)PHENOL	2008	Krysin Aleksej Petrovich Kusov Soltan Zaurbekovich Malykhin Evgenij Vasil'Evich	RU2385858C2
4-HYDROXY-2,6-DIHYDROXYIMINOCYCLOHEXANONE AS A PARENT PRODUCT FOR SYNTHESIS OF 4-HYDROXYBENZOFURAZAN, AND A METHOD OF 4-HYDROXYBENZOFURAZAN SYNTHESIS	1987	Volodarskij L.B. Samsonov V.A.	RU1589598C

RU 2 100 341 C1

Authors

Krysin A.P.

Vasilevskaja T.N.

Knjazev V.V.

Akhmetova N.E.

Egorova T.G.

Jakovleva O.D.

Dates

1997-12-27—Published

1996-05-30—Filed