METHOD OF SYNTHESIS CHLOROAZINES CONTAINING O-HYDROXYPHENYL GROUP Russian patent published in 1995 - IPC

FIELD: organic chemistry. SUBSTANCE: method involves synthesis of chloroazines containing o-hydroxyphenyl group of the formulas (I) HOC₆H₄, (II) CH₃ and (III) HOC₆H₄ where Ia - 4-Cl, 2-o-CF₃, R - 6-HOC₆H₄; Ib - 4-Cl, 2-o-C₆H₅, R - 6-HOC₆H₄; Ic - 4-Cl, 2-o-HOC₆H₄, R - 6-COOC₂H₅; Id - 4-Cl, 2-o-HOC₆H₄, R - 5-CN; Ie - 4-Cl, 2-o-C₆H₅, R - 5-o-HOC₆H₄; If - 4-Cl, 2-o-HOC₆H₄, R - 5-HOC₆H₄; Ig -4-Cl, 2-o-HOC₆H₄, R - H; Ih - 4-Cl, 6-o-C₆H₅, R - H; Ii - 4-Cl, 2-o-OC₃H₇, R - H; Ij - 4-Cl, 4-o-NO₂, R - 6-; IIa - R - H; IIb - R - 4-; IIc - R - 5-Br; IId - R - 5-; IIe - R - 3,5-Cl; IIIa - R - H. Reagent 1: (o-hydroxyphenyl)-dihydroazinones. Reagent 2: chloroanhydrides of organic or inorganic acids (phosphoryl chloride, phosphorus trichloride, thionyl chloride, cyanurchloride, phosphorus pentachloride). Process is carried out in the medium of dimethylformamide at molar ratio of reagents 1:2. Synthesized compounds are used in medicinal industry. EFFECT: improved method of synthesis. 2 cl