INJECTION LYOPHILIZED PREPARATIONS CONTAINING ANTHRACYCLINE GLYCOSIDES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS Russian patent published in 1998 - IPC

FIELD: medicine, pharmacy. SUBSTANCE: lyophilized injection preparation has an anthracycline glycoside or its pharmaceutically acceptable salt, inert vehicle and one or some solubilizing agents. The latter were taken from: mercapto- and amino-substituted benzoic acid, its C₁-C₄-alkyl esters, hydroxybenzoic acid, its C₁-C₄-alkyl esters, alkaline metal salts of these acids and ring-halogenated methyl-substituted phenol, for exception of a mixture of 0.4 mas. p. p-hydroxybenzoic acid methyl ester and 0.1 mas. p. p-hydroxybenzoic acid propyl ester. Preparation has 5-10 mas. p. p. inert vehicle and 0.01-1 mas. p. solubilizing agent per 1 mas. p. anthracycline glycoside. Preferable anthracycline salt is hydrochloride, anthracycline glycoside - doxorubicin, 4¹-epidoxorubicin, 4¹-deoxydoxorubicin, daunorubicin and 4-demethoxydaunorubicin; solubilizing agent - p-hydroxybenzoic acid methyl ester and inert vehicle - lactose. The following composition is preferable: 4-epidoxorubicin hydrochloride, lactose and p-hydroxybenzoic acid methyl ester. Invention proposes the antitumor lyophilized preparation containing anthracycline glycoside or its pharmaceutically acceptable salt, inert vehicle and one or some solubilizing agents at the indicated preferable ratio of components. EFFECT: enhanced effectiveness of preparation. 12 cl, 4 tbl