FIELD: pharmacy. SUBSTANCE: invention proposes lyophilized composition consisting of: conjugate including polymer on the basis of N-alkylmethacrylate and anthracycline glycoside bound with copolymer through peptide spacer; cosolubilizing agent and optionally containing filling agent. The end fragment can be bound with conjugate copolymer through peptide spacer. Solution for conjugate injection is prepared by lyophilized composition reduction. Composition can be used for treatment of patients with tumor. EFFECT: enhanced effectiveness of compositions. 12 cl, 10 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| BIOLOGICALLY-ACTIVE POLYMER-BOUND ANTHRACYCLINES, INTERMEDIATES, PREPARATION METHODS, AND PHARMACEUTICAL COMPOSITION | 1994 |
|
RU2145965C1 |
| POLYMERIC CONJUGATE, PHARMACEUTICAL COMPOSITION | 1994 |
|
RU2149646C1 |
| DEVICE FOR NEEDLE FITTING AND ITS DESIGN | 1992 |
|
RU2110263C1 |
| DERIVATIVES OF 3'-AZIRIDINO-ANTHRACYCLINE, METHODS OF SYNTHESIS, PHARMACEUTICAL COMPOSITION | 1994 |
|
RU2149163C1 |
| BINDING AGENT FOR BIOACTIVE PREPARATIONS, METHOD OF ITS SYNTHESIS AND PHARMACEUTICAL COMPOSITIONS | 1991 |
|
RU2116087C1 |
| ANTHRACYCLINE GLYCOSIDE, METHOD OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION | 1992 |
|
RU2118328C1 |
| POLYMERIC CONJUGATE, A METHOD OF ITS SYNTHESIS AND A PHARMACEUTICAL COMPOSITION | 1993 |
|
RU2130462C1 |
| TERPENOID DERIVATIVES AS USEFUL ANTITUMOR AGENTS | 1996 |
|
RU2179441C2 |
| AZAANTRACYCLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION | 1996 |
|
RU2159245C2 |
| INJECTION LYOPHILIZED PREPARATIONS CONTAINING ANTHRACYCLINE GLYCOSIDES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1992 |
|
RU2101018C1 |
