ANTHRACYCLINE GLYCOSIDE, METHOD OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION Russian patent published in 1998 - IPC

FIELD: organic chemistry, antibiotics. SUBSTANCE: invention relates to an anthracycline glycoside of the general formula (I) where R₁ - hydrogen or methoxy-group; R₂ - hydrogen or hydroxy-group; A and B - both hydrogen or one of A and B - hydrogen and other - hydroxy-group or group of the formula OSO₂P₅ where R₅ - C₁-C₄-alkyl arbitrarily substituted with C₁-C₄-alkyl, nitro-, amino-, methoxy-group or halogen; R₃ - hydrogen atom or group of the formula (2) and R₄ - group of the formula (2): (CH₂)_n-X where n = 2 or 3; X - hydroxy-group, halogen or group of the formula OSO₂P₅ where R₅ - as indicated above at condition that if R₂, X and A - hydroxy-group and R₃ - H then n must be 3, or its pharmaceutically acceptable salt. Synthesized compounds show antitumor activity. Invention proposes methods of their synthesis and pharmaceutical composition based on thereof. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 8 cl, 17 tbl, 7 ex