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Application

96107832/04, 1996-04-16

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Actual filing date

1996-04-16

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Published

1998-01-10

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Inventor

Korovkin B.F.Archakov A.I.Sergeev P.V.Shimanovskij N.L.Gorodetskij V.K.Tochilkin A.I.Kovel'Man I.R.Balabolkin M.I.Golubev M.A.Viktorova L.N.

(73)

Holder

Nauchno-Issledovatel'Skij Institut Biomeditsinskoj Khimii Ramn

OXOVANADIUM COMPLEXES OF L-MALIC ACID SHOWING HYPOGLYCEMIC ACTIVITY Russian patent published in 1998 - IPC

Abstract RU 2101287 C1

FIELD: organometallic chemistry. SUBSTANCE: invention relates to development of new chemical compounds showing HYPOGLYCEMIC effect - new complex system of oxovanadium (IV) (vanadyl) with malic acid of the formula: where a: R - H; b: R - Na. Synthesis is carried out from oxovanadyl (IV) hydroxide and L-malic acid or sodium L-hydromalate. The synthesized complexes Ia and Ib decreased blood glucose concentration in rats with experimental (streptozotocin) diabetes mellitus. Invention relates to new oral antidiabetic agents. EFFECT: improved method of synthesis. 3 tbl

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RU 2 101 287 C1

Authors

Korovkin B.F.

Archakov A.I.

Sergeev P.V.

Shimanovskij N.L.

Gorodetskij V.K.

Tochilkin A.I.

Kovel'Man I.R.

Balabolkin M.I.

Golubev M.A.

Viktorova L.N.

Dates

1998-01-10—Published

1996-04-16—Filed

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