N-(2,4,6-TRIMETHYLPHENYLCARBAMOYLMETHYL)-N-ALLYLMORPHOLINIUM BROMIDE SHOWING ANTIISCHEMIC AND ANTIARRHYTHMIC EFFECTS AT ISCHEMIC HEART DISEASE AND A METHOD OF ITS SYNTHESIS Russian patent published in 1998 - IPC

FIELD: organic chemistry. SUBSTANCE: product: new chemical compound - N-(2,4,6-trimethylphenylcarbamoyl)-N-allylmorpholinium bromide of the formula (I) . Method of synthesis of compound (I) involves interaction of N-(2,4,6-trimethylphenylcarbamoyl- -methyl)-morpholine with allyl bromide at mole ratio = 1:(1.4-1.6), respectively, in isopropyl alcohol medium at 55-65 C followed by separation of the end product after reaction mass cooling to the room temperature. Yield is 90%, content of basic substance is 99%, not less. Synthesized compound shows antiischemic and antiarrhythmic effects in animal experiments and under clinic conditions and can be used for making perspective medicinal agent for ischemic heart disease treatment. EFFECT: improved method of synthesis, increased yield and purity. 2 cl, 9 tbl