QUINOLONE-AND NAPHTHIRIDONECARBOXYLIC ACID DERIVATIVES IN ADMIXTURE WITH ISOMERS OR INDIVIDUAL ISOMERS, HYDRATES AND SALTS THEREOF, AND PHARMACEUTICAL COMPOSITION Russian patent published in 1998 - IPC

FIELD: medicine. SUBSTANCE: present invention describes quinolone-and napthyridonecarboxylic acid derivatives of formula I: wherein A is CH, CF, CCL, C-OCH₃, C-CH₃ and N′,; X¹ is hydrogen, halogen, NH₂, and CH₃; R¹ is alkyl having 1-3 carbon atoms, FCH₂CH₂-, cyclopropyl, phenyl which is mono-to trisubstituted by halogen: or A and R¹ are C-O-CH₂-CH(CH)₃ bridge; R² is hydrogen, alkyl having 1-3 carbon atoms which is substituted by hydroxy group, halogen or amino group, or 5-methyl-2-oxo-1,3-dioxol-4-yl-methyl; 8 is residue of formulae; wherein Y is 0 or CH₂; R³ is oxoalkyl having 2-5 carbon atoms; CH₂-CO-C₆H₅, CH₂CH₂CO₂R′, , CH=CH-CO₂R′ or CH₂CH₂-CN wherein R′ is hydrogen or alkyl having 1-3 carbon atoms, R⁴ is hydrogen, alkyl having 1-3 carbon atoms, oxoalkyl having 2-5 carbon atoms, CH₂-CO-C₆H₅, CH₂CH₂CO₂R′, R′O₂C-CH=C-CO₂R′, or CH₂CH₂-CN or 5-methyl-2-oxo-1,3-dioxol-4-yl methyl wherein R′ is hydrogen or alkyl having 1-3 carbon atoms, in admixture with isomers or individual isomers, hydrates and salts thereof. The present invention also describes method of preparation of drug containing said compounds. EFFECT: improved properties of the drug. 5 cl, 1 dwg, 4 tbl