DERIVATIVES OF 7-ISOINDOLINYLQUINOLONE AND 7-ISOINDOLINYLNAPHTHYRIDONE Russian patent published in 1998 - IPC

FIELD: organic chemistry. SUBSTANCE: invention relates to derivatives of 7-isoindolinylquinolone and 7-isoindolinylnaphthyridone where R¹ means C₁-C₄-alkyl possibly substituted with 1-3 fluorine atoms, C₃-C₆-cycloalkyl, phenyl possibly substituted with one or two fluorine atoms, 3-oxoprop-2-yl; R² - hydrogen; R³ - OH, OR″; R″ - -C₁-C₄-alkyl; R⁴ - hydrogen, NH₂, C₁-C₄-alkylamino, di-(C₁-C₃)-alkylamino; R⁵ - hydrogen, halogen; R⁶ - hydrogen, C₁-C₄-alkoxycarbonyl, hydroxymethyl, or where R¹² - hydrogen, C₁-C₃-alkyl possibly substituted with hydroxy-group, C₁-C₄-alkylhydroxycarbonyl; R¹³ - hydrogen, methyl; A means N or -C-R¹⁴ where R¹⁴ - hydrogen, halogen, and their tautomers and hydrochlorides. Synthesized compounds show strong antibiotic activity, low toxicity and can be used in medicine. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 1 tbl