FIELD: organic chemistry, pharmacy.
SUBSTANCE: invention relates to crystalline 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-[4.3.0]-nonane-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid semihydrochloride of the formula
. Also, invention describes a medicinal agent eliciting antibacterial properties based on this compound. Invention provides preparing the novel form of 8-cyano-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-[4.3.0]-nonane-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid showing good solubility in water.
EFFECT: valuable properties of compound.
5 cl, 6 dwg, 2 tbl, 11 ex
| Title |
Year |
Author |
Number |
| 8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYCLO-[4,3,0]-NONANE-8-YL)-6- FLU ORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID OF CRYSTALLINE MODIFICATION B AND MEDICINAL AGENT BASED ON THEREOF ELICITING EFFECT AGAINST PATHOGENIC MICROORGANISMS |
1999 |
- Khimmler Tomas
- Khallenbakh Verner
- Rast Khubert
|
RU2248355C2 |
| 8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYCLO-[4,3,0]-NONANE-8-YL)-6- FLU ORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID OF CRYSTALLINE MODIFICATION D AND MEDICINAL AGENT ELICITING EFFECT AGAINST PATHOGENIC MICROORGANISMS |
2000 |
- Khimmler Tomas
- Rast Khubert
|
RU2248357C2 |
| 8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYCLO-[4,3,0]-NONANE-8-YL)-6- FLU ORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID OF CRYSTALLINE MODIFICATION C AND MEDICINAL AGENT ELICITING EFFECT AGAINST PATHOGENIC MICROORGANISMS |
2000 |
- Rast Khubert
- Khimmler Tomas
|
RU2248356C2 |
| 8-CYANO-1-CYCLOPROPYL-7-(1S,6S)-2,8-DIAZABICYCLO- [4.3.0]-NONANE-8-YL)-6- FL UORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID WITH CRYSTALLINE MODIFICATION A AND DRUG ELICITING EFFECT AGAINST PATHOGENIC MICROORGANISMS |
1999 |
- Khimmler Tomas
- Khalenbakh Verner
- Rast Khubert
|
RU2247122C2 |
| TRIHYDRATE OF 8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYLCO-[4,3,0]NONAN-8-YL)-6-FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACID |
2005 |
- Rast Khubert
- Kheep Iris
- Grunenberg Al'Fons
- Khallenbakh Verner
- Bennet-Bukhkhol'Ts Khordi
|
RU2383543C2 |
| FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITION ELICITING ANTI-BACTERIAL ACTIVITY |
1997 |
- Shtefan Bartel'
- Tomas Ech
- Tomas Khimmler
- Khans-Georg Rast
- Verner Khallenbakh
- Ehrnst Khajnen
- Frants Pirro
- Martin Sheer
- Mikhael' Shtegemann
- Khans-Peter Shtupp
- Khajnts-Georg Vettsshtajn
|
RU2173318C2 |
| QUINOLONE-AND NAPHTHIRIDONECARBOXYLIC ACID DERIVATIVES IN ADMIXTURE WITH ISOMERS OR INDIVIDUAL ISOMERS, HYDRATES AND SALTS THEREOF, AND PHARMACEUTICAL COMPOSITION |
1993 |
- Uve Peterzen[De]
- Andreas Krebs[De]
- Tomas Shenke[De]
- Tomas Filipps[De]
- Klaus Groeh[De]
- Klaus-Diter Bremm[De]
- Rajner Ehndermann[De]
- Karl-Georg Mettsger[De]
- Ingo Khaller[De]
|
RU2105770C1 |
| DERIVATIVES OF QUINOLINE CARBOXYLIC ACID, MIXTURE OF ISOMERS OR INDIVIDUAL ISOMERS, THEIR PHARMACEUTICALLY ACCEPTABLE HYDRATES AND SALTS, METHOD FOR THEIR PRODUCTION |
1992 |
- Uve Petersen[De]
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- Tomas Shenke[De]
- Andreas Krebs[De]
- Klaus Grokhe[De]
- Klaus-Diter Bremm[De]
- Karl-Georg Mettsger[De]
- Rajner Ehndermann[De]
- Khans-Joakhim Tsejler[De]
|
RU2077533C1 |
| QUINOLONE- AND NAPHTHIRIDONECARBOXYLIC ACID DERIVATIVES, MIXTURE OF THEIR ISOMERS OR INDIVIDUAL ISOMERS IN THE FORM OF HYDRATES AND SALTS SHOWING ANTIBACTERIAL ACTIVITY, ISOINDOLE DERIVATIVES AS INTERMEDIATES FOR PREPARATION OF SAID QUINOLONE- AND NAPHTHIRIDONECARBOXYLIC ACID DERIVATIVES |
1995 |
- Uve Petersen
- Tomas Shenke
- Klaus-Diter Bremm
- Rajner Ehndermann
|
RU2145604C1 |
| METHOD OF PRODUCING SUBSTITUTED DIAZOBYCYCLOALKYLOQUINOLONE CARBOLIC ACIDS WITH BRIDGE BONDS OR THEIR PHARMACEUTICALLY ACCEPTABLE ADDITIVE SALTS |
0 |
- Martin Rajmond Dzhefson
- Pol Robert Ma.Gvirk
|
SU1482531A3 |
