3 CODING POLYPEPTIDE K2P WITH PLASMINOGEN ACTIVATOR PROPERTIES, AND PHARMACEUTICAL COMPOSITION WITH FIBRINOLYTIC ACTIVITY. FIELD: biotechnology. SUBSTANCE: polypeptide k2p is prepared via transformation of bacterial strain by recombinant plasmida DNA pA27.3 including fragment coding above-indicated polypeptide and having following characteristics: fibrinolytic activity 550000 ± 200000 un/mg, molecular weight 38500 ± 2000 Da, increased half-value period as compared to natural analogue, fibrin- related stimulation, trombolytic activity, and solubility in arginine solution in concentration 10-1000 mmol/l when purity of product is 95%. Obtained are also pharmacological composition containing indicated polypeptide in effective amount and pharmacologically acceptable carrier. EFFECT: provided new useful pharmacological composition. 4 cl, 7 dwg, 10 tbl
| Title |
Year |
Author |
Number |
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- Gerd Jozef Shteffens[De]
- Vol'Fgang Amandus Gjuntsler[De]
- Leopol'D Floe[De]
- Regina Ehl'Fride Brigelius-Floe[De]
- Bernkhard Vol'F[De]
|
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1990 |
- Regina E.Brigelius-Floeh[De]
- Leopol'D Floeh[De]
- Vol'Fgang Khillen[De]
- Gerd I.Shteffens[De]
- Vol'Fgang Shtrassburger[De]
- Martin R.F.Vil'Khel'M[De]
|
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0 |
- Rajner Rudolf
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- Ralf Mattes
|
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- Skrypina Natalija Alekseevna
- Feoktistova Evgenija Sergeevna
|
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- Khans-Jorg Markl
- Khajnrikh Voog
|
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|
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2001 |
- Gurskij Ja.G.
- Belogurov A.A.
- Bibilashvili R.Sh.
- Grigor'Eva N.V.
- Del'Ver E.P.
- Minashkin M.M.
|
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1994 |
- Gerd J. Shteffens
- Stefan Vnendt
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- Regina Khajntsel'-Viland
- Derek Dzhon Sonders
|
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1988 |
- Jasusi Kavauti[Jp]
- Tosijuki Takemoto[Jp]
- Makoto Takajama[Jp]
- Masami Ekota[Jp]
- Masao Kato[Jp]
- Kimio Katsuta[Jp]
- Khirosi Gusima[Jp]
|
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2012 |
- Grigor'Eva Ol'Ga Vasil'Evna
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- Karpov Andrej Pavlovich
- Petrov Andrej Vladimirovich
- Fabrichnyj Igor' Pavlovich
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|
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