FIELD: organic chemistry; medicine. SUBSTANCE: derivatives of 3-oxadiazolyl-5,6,7,8-tetrahydro-1,6-naphtiridine are prepared by intramolecular cyclization of suitable acetylsemicarbazides or 1,2-di(R-carbamoyl)hydrazines, the process takes place in the presence of dehydration agent. Desired 6-benzyl-3-(5-methylthio-1,3,4-oxadiazole-2-yl)-5,6,7,8-tetrahydro-1,6- naphtiridine-2(1H)-on is prepared at 55.5 % yield, its melting point being 215-217 C. EFFECT: improved quality of desired product. 10 cl, 8 tbl
| Title |
Year |
Author |
Number |
| DERIVATIVES OF 5-SUBSTITUTED-3-OXADIAZOLYL-1,6-NAPHTHYRIDINE-2(1H)-ONE, PHARMACEUTICAL COMPOSITION AND DERIVATIVES OF 1,6-NAPHTHYRIDINE-2(1H)-ONE |
1998 |
- Okhno Kazunori
- Odai Osamu
- Masumoto Kaoru
- Furukava Kijosi
- Oka Makoto
|
RU2188199C2 |
| METHOD OF PRODUCING DERIVATIVES OF 1,8-NAPHTYRINE OR THEIR SALTS |
0 |
- Dzyun-Iti Matsumoto
- Siniti Nakamura
- Teruyuki Miyamoto
- Khitosi Uno
|
SU1482527A3 |
| DERIVATIVES OF PYRIDONE CARBOXYLIC ACID, METHODS OF THEIR SYNTHESIS, ANTITUMOR AGENT AND PHARMACEUTICAL COMPOSITION |
1995 |
- Tomita Kodzi
- Tiba Katsumi
- Kasimoto Sigeki
- Sibamori Kokh-Itiro
- Tsuzuki Jasunori
|
RU2151770C1 |
| PROCESS FOR PREPARING DERIVATIVES OF 1,8-NAPHTHYRIDINE-3-CARBOXYLIS ASID OR THEIR SALTS |
0 |
- Yun-Iti Matsumoto
- Esiyuki Takase
- Esiro Nisimura
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SU1060112A3 |
| VERSIONS OF METHOD OF PRODUCING DERIVATIVES OF 1,8-NAPHTHYRIDINE OR ACID-ADDITIVE SALTS THEREOF |
0 |
- Yun-Iti Matsumoto
- Yundzi Nakano
- Katsumi Tiba
- Siniti Nakamura
|
SU1456015A3 |
| ACETAMIDE DERIVATIVES (VARIANTS), METHOD OF PREPARATION THEREOF (VARIANTS), PHARMACEUTICAL COMPOSITION AND AGENT |
1996 |
- Teruja Murata
- Kehtsukhiko Khino
- Kiesi Furukava
- Makoto Oka
- Mari Itokh
|
RU2160256C2 |
| METHOD OF PRODUCING DERIVATIVES OF 1,8-NAPHTHIRIDINE OR SALTS THEREOF |
0 |
- Dzyun-Iti Matsumoto
- Siniti Nakamura
- Teruyuki Miyamoto
- Khitosi Uno
|
SU1445558A3 |
| PROCESS FOR PREPARING DERIVATIVES OF 1,8-NAPHTHYRIDINE OR THEIR SALTS |
0 |
- Yun-Iti Matsumoto
- Esiyuki Takase
- Esiro Nisimura
|
SU1075976A3 |
| THIOPHENE DERIVATIVE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1997 |
- Kimura Takenori
- Murakami Takesi
- Okhmori Dzunija
- Morita Takuma
- Tsukamoto Sin-Iti
|
RU2172737C2 |
| DERIVATIVES OF 1-[ω-(3,4-DIHYDRO-2-NAPHTHALINYL)ALKYL]- -CYCLIC AMINE AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF |
1996 |
- Naoki Kaj
- Aki Kanekhira
- Tosija Morie
- Katsukhiko Khino
- Katsuesi Kavasima
- Isao Simizu
- Kazukhisa Akijama
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RU2142453C1 |
