FIELD: organic chemistry. SUBSTANCE: invention proposes derivatives of cycloalkyl-substituted glutaric acid amide of the general formula (I): 
where: A - (CH2)4,(CH2)5; R1- - H, (C1-C4)-alkyl; R and R4 - H, (C1-C4)-alkyl, (C3-C7)-cycloalkyl, benzyl or biolabile ester-forming group; Y - simple bond, (C1-C6)-alkylene; R2- - H, phenyl, R6CONR5- or R7NR5CO-; R3 means group of formula (II), or their pharmaceutically acceptable salts or biolabile ester. Invention proposes also pharmaceutical composition that inhibits activity of angiotensin-converting enzyme and neutral endopeptidase based on compounds of the formula (I) 
. EFFECT: improved method of synthesis. 14 cl, 15 tbl
| Title |
Year |
Author |
Number |
| METHOD OF SYNTHESIS OF CYCLOALKYLGLUTARAMIDE DERIVATIVES OR THEIRS PHARMACEUTICALLY ACCEPTABLE SALTS |
1989 |
- Dzhon Kristofer Danilevich[Gb]
- Kejt Dzhejms[Gb]
- Richard Jurek Kobileki[Gb]
|
RU2012556C1 |
| 1,2,4-TRIAZOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITION AND INTERMEDIATE COMPOUNDS |
1992 |
- Rodzher Piter Dikinson[Gb]
- Kennet Richardson[Gb]
|
RU2095358C1 |
| METHOD OF SYNTHESIS OF PYRAZOLOPYRIMIDINE COMPOUNDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS |
1991 |
- Ehndrju Sajmon Bell[Gb]
- Dehvid Braun[Gb]
- Nikolas Kennet Terrett[Gb]
|
RU2047617C1 |
| METHOD OF SYNTHESIS OF TRIAZOLE DERIVATIVES |
1991 |
- Stefen Dzhejms Rehj[Gb]
- Kennet Richardson[Gb]
|
RU2036194C1 |
| SUBSTITUTED PYRAZOLES, PHARMACEUTICAL COMPOSITION BASED ON SAID, METHOD OF PATIENT TREATMENT, INTERMEDIATE COMPOUND |
1993 |
- Dzhen M.Brajt
- Uillard M.Uehlch
|
RU2130453C1 |
| INDOLE DERIVATIVES, THEIR OPTICAL ISOMERS AND PHARMACEUTICALLY ACCEPTABLE SALTS |
1991 |
- Dzhon Judzhin Makor[Us]
- Martin Dzhejms Vites[Gb]
|
RU2095360C1 |
| BENZOAKANIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITION |
1993 |
- Rodzher Piter Dikinson[Gb]
- Kevin Nejl Dehk[Gb]
- Dzhon Stil[Gb]
|
RU2110512C1 |
| PYRAZOLOPYRIMIDINONE COMPOUNDS, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT |
1991 |
- Ehndrju Simon Bell
- Dehvid Braun
- Nikolas Kennet Terrett
|
RU2114114C1 |
| PROCESS FOR PRODUCING ESTERS OF 1,1-DIOXIDE OF PENICILLANIC ACID |
0 |
|
SU944505A3 |
| 2-(4-HYDROXYPIPERIDINO)-1-ALKANOL DERIVATIVES AND 2-(4- HYDROXYPIPERIDINO)-1-ALKANONE DERIVATIVES |
1992 |
|
RU2065859C1 |
