SUBSTITUTED PYRAZOLES, PHARMACEUTICAL COMPOSITION BASED ON SAID, METHOD OF PATIENT TREATMENT, INTERMEDIATE COMPOUND Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of pyrazole of the general formula (I) or their pharmaceutically acceptable acid additive salts where A means CH₂; R₁ is C_1-6-alkyl or phenyl; X₁ - covalent bond or S; R₃ is C_1-6-alkyl; Y is 2,4,6-trisubstituted phenyl where a substituent is taken from chlorine atom, methyl- or trifluoromethyl-group being phenyl has not more one trifluoromethyl-group as a substituent; Z - a group of the formula (a) where R₄ - H or C_1-6-alkoxy-group; R₅ - H, -CH₂OR₆; R₆ - H or C_1-6-alkyl; or a group of the formula (b) where K and J - CH or one of them means CH and another - nitrogen; R₁₄ - hydroxy-, alkoxy-group or a group X₂-(CH₂)_rOR₆ where X₂ - covalent bond or oxygen atom; r = 1 or 2. Compounds show an activity of antagonists of corticotropin-releasing factor. EFFECT: enhanced effectiveness of compounds and composition as antagonists. 9 cl, 4 tbl, 13 ex