FIELD: organic chemistry. SUBSTANCE: product: new derivatives of imidazole of the formula 
showing antagonistic activity with respect to angiotensin-II. Pharmaceutical composition has an effective amount of an active compound of the formula indicated above and conventional special additions. The following compounds are preferable as antagonists: (R)-1-[1- -oxo-2-[4-(2-sulfobenzoyl)-amino-1H-imidazole-1-yl] -octyl] -4- -cis-(4-carboxymethylphenoxy)-L-proline and (R)-1-(1-oxo-2- -[4-(2-sulfobenzoyl)-amino-1H-imidazole-1-yl] -octyl] -4-cis- -[(4-methylenephosphonic acid)-phenoxy]-L-proline. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 7 cl, 2 tbl
