FIELD: pharmaceutical industry. SUBSTANCE: antagonists having substituted phenylphenol structure and different derivatives thereof are specific leukotriene antagonists. Present invention describes structure, use and synthesis thereof and discloses pharmaceutical compositions useful for treating diseases and states which are peculiar in that B4 leucotriene, one of araquilonic acid metabolites, is heavily released. B4 leukotriene antagonists are represented by formula: 
wherein R1, R2, R3, R4, X, Y, Z and A are as defined in the specification. Present invention also describes method for preparing intermediate compounds of formula XI: 
wherein R21, R22 and R23 and T are as defined in the specification. EFFECT: improved properties of the title compounds. 23 cl, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| CEPHALOSPORIN DERIVATIVES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, PHARMACEUTICAL COMPOSITION | 1992 |
|
RU2104280C1 |
| 1,3-SUBSTITUTED SULFONYLUREAS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS SHOWING ANTITUMOR ACTIVITY | 1991 |
|
RU2022963C1 |
| BENZOTHIOPHENE COMPOUNDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1996 |
|
RU2158737C2 |
| PYRAZOLE DERIVATIVES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS | 1991 |
|
RU2076100C1 |
| TRIPEPTIDE DERIVATIVES AS R- OR RS-FORMS OR THEIR PHARMACEUTICALLY ACCEPTABLE NONTOXIC SALTS, PHARMACEUTICAL COMPOSITION | 1991 |
|
RU2077538C1 |
| METHOD OF SYNTHESIS OF 3-EXOMETHYLENECEPHAME SULFOXIDE ESTER | 1992 |
|
RU2010795C1 |
| METHOD OF SYNTHESIS OF 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALT | 1989 |
|
RU2014330C1 |
| DERIVATIVES OF 1-CARBA-(1-DETIA)-CEPHEME | 1993 |
|
RU2107067C1 |
| METHOD OF TRICYCLE COMPOUNDS SYNTHESIS | 1991 |
|
RU2007401C1 |
| PROCESS FOR PREPARING TETRAZOLE DERIVATIVES | 1989 |
|
RU2015976C1 |
