FIELD: organic chemistry. SUBSTANCE: quinazoline derivatives of the formula (I) $$$, its pharmaceutically acceptable salt or ester where $$$ - $$$-alkyl; $$$ - hydrogen, $$$-alkyl; $$$ - $$$-alkyl, $$$-alkenyl, $$$-alkynyl; Ar - phenylene that can has optionally one or two substituents taken from halogen, $$$-alkyl, $$$-alkoxy or pyridine-diyl. Quinazoline ring can has optionally a substituent at one of 5-, 7- and 8-positions taken from halogen and $$$-alkyl. Compound (I) $$$ is synthesized by interaction of acid of the formula (II) $$$ with compound of the formula (III) $$$ where $$$ have indicated values and $$$ - hydrogen or protective group; $$$ - protective group. Protective groups are removed by conventional method. Compound (I) $$$ is used as an active component in pharmaceutical composition exhibiting antitumor activity. EFFECT: improved method of synthesis. 12 cl, 2 tbl
Title |
Year |
Author |
Number |
QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS OF VESSEL ENDOTHELIUM GROWTH FACTOR |
1997 |
- Tomas Ehndrju Peter
- Dzhonstoun Krehjg
- Ehnnekehn Loran Fransua Andre
|
RU2196137C2 |
QUINAZOLINE DERIVATIVES, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION, AND A METHOD FOR REACHING ANTIPROLIFERATIVE EFFECTS |
1996 |
|
RU2153495C2 |
DERIVATIVES OF QUINAZOLINE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, A METHOD OF THEIR SYNTHESIS AND A PHARMACEUTICAL COMPOSITION BASED ON SAID |
1993 |
|
RU2127263C1 |
DERIVATIVES OF QUINAZOLINE, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION COMPRISING THEREOF AND METHOD OF ACHIEVEMENT OF ANTI-ANGIOGENIC EFFECT AND/OR EFFECT OF DECREASE OF VASCULAR PENETRATION WITH THEIR USING |
1996 |
- Lomann Zhan-Zhak Marsel'
- Ehnneken Loran Fransua Andre
- Tomas Ehndrju Piter
|
RU2194701C2 |
DERIVATIVES OF QUATERNARY AMINOPYRIMIDINE AND PHARMACEUTICAL COMPOSITION |
1990 |
- Rodni Brajan Khargrivs[Gb]
- Pol Vill'Jam Marshall[Gb]
- Bernard Dzhozef Makloglin[Gb]
- Stjuart Dennet Millz[Gb]
|
RU2108329C1 |
PHYSICAL FOAM OF (R)-3-METHOXY-4-1-METHYL-5- 2-METHYL- 4,4,4-TRIFLUOROBUTYLCARBAMOYL) INDOL-3-YLMETHYL-N-(2- METHYLPHENYL-SULPHONYL)BENZAMIDE, PHARMACEUTICAL COMPOSITION HAVING PROPERTIES OF LEUCOTRIENE ANTAGONIST |
1992 |
- Murrej Vatson Katbert[Gb]
|
RU2095348C1 |
DERIVATIVES OF NITROGENOUS YPERITE BOUND WITH AMINO ACIDS THAT ARE PRODRUG SUBSTRATES FOR CARBOXYPEPTIDASE ENZYME, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND BIOCOMPONENT SYSTEM FOR CYTOTOXIC DRUG DELIVERY |
1993 |
- Filip Dzh.Berk
- Robert I.Dauehll
- Ehntoni B.Mauger
- Karolin Dzh.Springer
|
RU2129542C1 |
CARBOPENEM DERIVATIVES, THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND HYDROLYZED IN VIVO ESTERS (VARIANTS), METHOD OF SYNTHESIS (VARIANTS), PHARMACEUTICAL COMPOSITION SHOWING ANTIBACTERIAL ACTIVITY, DERIVATIVES OF PYRROLIDINE-4-YLTHIOL AND PROTECTED DERIVATIVES OF PYRROLIDINE-4-YLTHIOL |
1993 |
- Majkl Dzhon Betts
- Garet Mors Dehvis
- Majkl Lingard Svejn
|
RU2117659C1 |
NEW COMPOUNDS |
2001 |
- Ehriksson Tomas
- Khenriksson Krister
|
RU2261245C2 |
DERIVATIVES OF 3-(5-TETRAZOLYLBENZYL)-AMINOPIPERIDINE, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION ON SAID |
1994 |
- Armur Dankan Robert
- Ehvans Brajan
- Midlmiss Dejvid
- Nehjlor Alan
- Pegg Nil Ehntoni
- Vajnejder Marija Viktorija
- Giblin Dzherard Martin Pol
- Khabbard Tanja
- Khehnn Majkl Mentehjt
- Ljuehll Zjao-King
- Uotson Stiven Pol
|
RU2136675C1 |