FIELD: organic chemistry. SUBSTANCE: product: compounds of the formula (I), their alkaline salts, and pharmaceutical composition containing these compounds. Substance (I): Q-SO2-CH2-NO2 where Q - unsubstituted naphthyl or naphthyl substituted with chlorine or methoxy-group, or phenyl substituted with 1, 2 or 3 substituents taken from the group: hydrogen, halogen, cyano-, hydroxy-, carboxy-, amino-, C1-C6-alkanoyl, C1-C6-alkanoylamino-, C1-C6-alkyl-, C3-C6-alkenyloxy-, fluoro-C1-C6-alkyl-, C1-C6-alkoxy-, fluoro-C1-C4-alkoxy-, hydroxy-C1-C6-alkyl-, carbamoyl-, C1-C6-dialkylcarbamoyl-, C1-C6-dialkylsulfamoyl-, C1-C6-alkaoxycarbonyl-, C1-C4-alkylenedioxy-, C1-C6-alkylthio-, C1-C6-alkylsulfinyl-, C1-C6-alkylsulfonyl-, chlorophenyl-, benzamido-, benzyloxy- or phenoxy-group; or Q - phenyl substituted with 4 halogens or 5 C1-C6-alkyl-groups, or Q - phenanthryl, exception for, when Q - unsubstituted phenyl, 4-fluoro-, 4-chloro-, 4-bromo-, 4-methyl-, 4-acetylamido- or 2-carboxyphenyl. Synthesized compounds were used in medicine for diabetes complication and galactosemia treatment and in biochemistry as aldoreductase inhibitors. EFFECT: improved method of synthesis. 8 cl, 4 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR SYNTHESIS OF NITROMETHANE DERIVATIVES OR THEIRS ALKALINE | 0 |
|
SU1773262A3 |
| METHOD OF NITROMETHANE DERIVATIVES OR THEIRS ALKALINE SALTS SYNTHESIS | 0 |
|
SU1804456A3 |
| (4-AMINO-2,6-DIMETHYLPHENYL SULFONYL)NITROMETHANE PHENYL ACETYL DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | 1991 |
|
RU2068409C1 |
| DERIVATIVES OF 1,3-DIOXANE ALKENOIC ACID | 1989 |
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RU2045526C1 |
| (4-AMINO-2,6-DIMETHYLPHENYLSULFONYL) NITROMETHANE, (4- ACETAMIDO-2,6-DIMETHYLPHENYLSULFONYL) NITROMETHANE AND PHARMACEUTICAL COMPOSITION HAVING PROPERTIES OF ALDOSOREDUCTASE ENZYME INHIBITOR | 1992 |
|
RU2034834C1 |
| METHOD FOR PRODUCTION OF 3-ALKYLATED INDOLE AND (2-NITROPHENYL)-ACETALDEHYDE | 1991 |
|
RU2054417C1 |
| DERIVATIVES OF QUATERNARY AMINOPYRIMIDINE AND PHARMACEUTICAL COMPOSITION | 1990 |
|
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| AMIDES, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING PROPERTY OF CHANNEL OPENING FOR CELLULAR POTASSIUM | 1992 |
|
RU2074173C1 |
| PROCESS FOR PREPARING (4-AMINO)-2,6-DIMETHYLPHENYLSULFONYL NITROMETHANE | 0 |
|
SU1817776A3 |
| PROCESS FOR PREPARING ACETYLENE DERIVATIVES OF CHROMAN OF THIOCHROMAN | 1990 |
|
RU2015969C1 |
