DERIVATIVES OF QUATERNARY AMINOPYRIMIDINE AND PHARMACEUTICAL COMPOSITION Russian patent published in 1998 - IPC

FIELD: organic chemistry. SUBSTANCE: invention relates to new aminopyrimidinium salts of the formula (I): where R¹ - alkyl, alkenyl, cycloalkyl, phenyl, phenylalkyl or cycloalkyl; one of R² and R⁶ - basic group taken from amino-, alkylamino-, dialkylamino- (length is up to 8 carbon atoms), pyrrolidino-, piperidino- and morpholino-; other of groups R² and R⁶ - hydrogen, alkyl, alkenyl, alkoxyalkyl, phenyl, phenylalkyl, cycloalkyl or cycloalkyl-alkyl; or both groups R² and R⁶ are basic groups as indicated above; group R⁵ - hydrogen, (1-4C)-alkyl or (3-6C)-alkenyl; or R² - basic group as indicated above, and R⁵ and R⁶ together form alkylene or together with carbon atoms of pyrimidine ring complete benzyl ring; R⁴ - hydrogen, alkyl, cycloalkyl-alkyl, alkenyl, alkynyl or phenylalkyl; or R⁴ can be substituted alkylene or alkenylene bound to nitrogen atom of group Q, A, N-, and each of these bound groups can completes the ring including two adjacent carbon atoms of Q-group, carbon atom of A-group and adjacent nitrogen atom of -A, N-group; A is bound directly to the -N-(R⁴)-group or is alkylene or hydroxyalkylene; Q is pyridyl, furyl, thienyl or phenyl residue; and Y is anion that is physiologically acceptable anion. Exception includes some compounds refined in further. Invention involves also definite closely related anhydrobasic derivatives of pyrimidine compounds thats as compounds of the formula (I) show beneficial effect on cardiovascular system (in part, they show beneficial effect decreasing the rate of sinus-atrium bundle). Invention includes also pharmaceutical compositions containing compounds of the formula (I) (or related anhydrobases) as an active component and processes for synthesis of different new compounds. EFFECT: improved method of synthesis. 9 cl, 30 tbl