COMPOSITION FOR ENTERIC COATING OF LECTIN-CONTAINING NATURAL PRODUCT Russian patent published in 2008 - IPC A61K9/50 A61K9/52 

FIELD: pharmaceutical technology, pharmacy.

SUBSTANCE: group of inventions relates to a composition of lectin-containing enteric coating, in particular, for mistletoe extract, and to composition for microcapsules with enteric coating containing lectin as a main component. Granulated composition comprises the following components, g: mannitol as an excipient, 115; Avicel PH 101, 18; calcium disubstituted phosphate, 17; hydroxypropylmethylcellulose, 20 as a binding solution; water, 100 ml; ethyl alcohol, 100 ml; Zein-DR, 25 g as a solution for applying a coating; shellac, 35 g and 80% ethyl alcohol, 180 ml wherein solution for applying a coating is prepared by dissolving 50 weight % of reagent for a coating and 50 weight % of a plasticizing agent. Composition for tableting of lectin-containing microcapsules with enteric coating comprises the following components, PLGA/CH₂Cl₂, 4 ml; 1% polyvinyl alcohol, 50 ml; Span-80, 2 ml as a surfactant; food oil, 48 ml; 1-4% sodium alginate solution, 8 ml, and 0.02-0.2 M CaCl₂ solution, 60 ml. Invention provides solution the problem associated with instability in digestive tract after oral administration that enhances effectiveness of a medicinal agent and effectiveness of treatment in therapeutic institutions.

EFFECT: improved, enhanced and valuable pharmaceutical properties of composition.

4 cl, 3 tbl, 2 dwg, 9 ex