FIELD: organic synthesis. SUBSTANCE: 3-quinolonecarboxylic acid derivatives having general formula I: 
(I), wherein R1 and R2 together with nitrogen atom to which they are linked form mono- or bicyclic heterocycle optionally containing one more endocyclic nitrogen atom and A is CH, CF, CCl, or C-OCH3 group, are prepared by reaction of compound with general formula II: 
(II), wherein Hal, X, and X' are fluorine or chlorine, with aminoacrylic acid ester III: 
(III). EFFECT: specified procedure and prevented formation of corrosive products contaminating desired product. 3 cl, 6 ex
| Title |
Year |
Author |
Number |
| DERIVATIVES OF QUINOLINE CARBOXYLIC ACID, MIXTURE OF ISOMERS OR INDIVIDUAL ISOMERS, THEIR PHARMACEUTICALLY ACCEPTABLE HYDRATES AND SALTS, METHOD FOR THEIR PRODUCTION |
1992 |
- Uve Petersen[De]
- Tomas Khimmler[De]
- Tomas Shenke[De]
- Andreas Krebs[De]
- Klaus Grokhe[De]
- Klaus-Diter Bremm[De]
- Karl-Georg Mettsger[De]
- Rajner Ehndermann[De]
- Khans-Joakhim Tsejler[De]
|
RU2077533C1 |
| QUINOLONE- AND NAPHTHIRIDONECARBOXYLIC ACID DERIVATIVES, MIXTURE OF THEIR ISOMERS OR INDIVIDUAL ISOMERS IN THE FORM OF HYDRATES AND SALTS SHOWING ANTIBACTERIAL ACTIVITY, ISOINDOLE DERIVATIVES AS INTERMEDIATES FOR PREPARATION OF SAID QUINOLONE- AND NAPHTHIRIDONECARBOXYLIC ACID DERIVATIVES |
1995 |
- Uve Petersen
- Tomas Shenke
- Klaus-Diter Bremm
- Rajner Ehndermann
|
RU2145604C1 |
| QUINOLONE- AND NAPHTYRIDONE CARBOCYLIC ACID DERIVATIVES AS MIXTURE OF ISOMERS OR INDIVIDUAL ISOMERS AND SALT THEREOF |
1994 |
- Shtefan Bartel'
- Andreas Krebs
- Frants Kunish
- Uve Peterzen
- Tomas Shenke
- Klaus Groeh
- Mikhaehl' Shriver
- Klaus-Diter Bremm
- Rajner Ehndermann
- Karl-Georg Mettsger
|
RU2114832C1 |
| METHOD FOR HYDROLYSIS OF QUINOLONOCARBOXIC ACID ETHERS |
2019 |
- Fey Peter
- Berwe Mathias
- Wirths Joerg
- Wischnat Ralf
- Longerich Markus
- Dietzel Antje
|
RU2794892C2 |
| METHOD FOR OBTAINING 1-CYCLOPROPYL-7-CHLOR-6-FLUOR-1, 4- DIHYDRO-4-OXO-3- -CHINOLINECARBOXYLIC ACID |
0 |
- Rudolf Tserbes
- Mikhael Prejss
|
SU1660582A3 |
| 8-CYANO-1-CYCLOPROPYL-7-(1S,6S-2,8-DIAZABICYCLO-[4,3,0]-NONANE-8-YL)-6-FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID SEMIHYDROCHLORIDE |
1999 |
- Khimmler Tomas
- Rast Khubert
|
RU2242475C2 |
| FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITION ELICITING ANTI-BACTERIAL ACTIVITY |
1997 |
- Shtefan Bartel'
- Tomas Ech
- Tomas Khimmler
- Khans-Georg Rast
- Verner Khallenbakh
- Ehrnst Khajnen
- Frants Pirro
- Martin Sheer
- Mikhael' Shtegemann
- Khans-Peter Shtupp
- Khajnts-Georg Vettsshtajn
|
RU2173318C2 |
| QUINOLONE-AND NAPHTHIRIDONECARBOXYLIC ACID DERIVATIVES IN ADMIXTURE WITH ISOMERS OR INDIVIDUAL ISOMERS, HYDRATES AND SALTS THEREOF, AND PHARMACEUTICAL COMPOSITION |
1993 |
- Uve Peterzen[De]
- Andreas Krebs[De]
- Tomas Shenke[De]
- Tomas Filipps[De]
- Klaus Groeh[De]
- Klaus-Diter Bremm[De]
- Rajner Ehndermann[De]
- Karl-Georg Mettsger[De]
- Ingo Khaller[De]
|
RU2105770C1 |
| OXIME DERIVATIVES, METHOD OF PREPARING THEREOF, FUNGICIDAL AGENT, AND METHOD OF CONTROLLING FUNGAL DISEASES |
1995 |
- Peter Gerdes
- Kherbert Gajer
- Bernd-Viland Krjuger
- Bernd Gallenkamp
- Khajnts-Vil'Gel'M Dene
- Shtefen Duttsmann
- Gerd Khehnssler
- Klaus Shtentsel'
|
RU2154629C2 |
| DERIVATIVES OF CYCLOHEXADIENE, MIXTURE OF THEIR ISOMERS OR SEPARATE ISOMERS AND THEIR SALTS AND PHARMACEUTICAL COMPOSITION WITH SELECTIVE MODULATING EFFECT ON CALCIUM-DEPENDENT POTASSIUM CHANNELS OF HIGH CONDUCTIVITY |
1995 |
- Klaus Urbans
- Khans-Georg Khejne
- Bodo Junge
- Rudol'F Shokhe-Loop
- Khartmund Vol'Veber
- Khenning Zommermejer
- Tomas Glazer
- Rejlinde Vittka
- Zhan-Mari-Viktor De Vri
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RU2155748C2 |
