ISATINE OR ISATINE OXIME DERIVATIVES, METHOD OF SYNTHESIS OF ISATINE OXIME AND A PHARMACEUTICAL COMPOSITION Russian patent published in 1998 - IPC

FIELD: organic chemistry. SUBSTANCE: invention describes compounds of the formula (I) where R⁴ and R⁵ - independently hydrogen, halogen, CF₃, CN, NO₂ or group SO₂NR¹R² where R¹ - hydrogen or C₁-C₆-alkyl that can be branched or cyclic; R² - hydrogen or C₁-C₆-alkyl that can be normal, branched or cyclic or where R¹ and R² form together group -(CH₂)_n-A-(CH₂)_m where A - O, S, CH₂ or NR^I where R^I - H, C₁-C₆-alkyl that can be normal, branched or cyclic; n = 0, 1, 2, 3, 4, 5 and m = 0, 1, 2, 3, 4, 5; Q - NOH or O; Z - O, S, N-R^II, , N-Q^IV-C(O)-N-R^V-, where R^II,R^III,R^IV,R^V - independently - hydrogen, benzyl, C₁-C₆-acyl, C₁-C₆-alkoxyl that can be branched or cyclic, or C₁-C₆-alkyl that can be branched or cyclic; X - -(CH₂) where o = 0, 1, 2 or 3; Y - -(CH₂)_p where p = 0, 1, 2 or 3; α и β - addition points. Invention describes pharmaceutical composition showing activity associated with blockade of glutamic and aspartic acid receptors using the synthesized compounds. EFFECT: improved method of synthesis. 9 cl