DERIVATIVES OF 4-CHLORO-2-THIOPHENE CARBOXYLIC ACID, METHOD FOR PRODUCTION OF 4-CHLORO-2-THIOPHENE CARBOXYLIC ACID (VARIANTS) AND METHOD FOR PRODUCTION OF 5-FLUORO-6-CHLORO-3-(4-CHLORO-2-THENOYL)-2-OXINDOLE-1-CARBOXAMIDE (VARIANTS) Russian patent published in 1998 - IPC

Abstract RU 2114854 C1

FIELD: organic chemistry, pharmaceutical industry. SUBSTANCE: 4-chloro-2-thiopheme carboxylic acid is prepared by interaction of 4-chloro-5-trimethylsilyl thiophene with suitable base, the process is carried out at temperature less than -50 C. Thus obtained suitable anion is treated with carbon dioxide, the process takes place at temperature less than -50 C and it is followed by removing of silyl group. Thus prepared product is used as intermediate by production of 5-fluoro-6-chloro-3/4-chloro-2-thenoyl/-2-oxyindole-1-carboxamide which possesses pharmaceutical activity. EFFECT: improved quality of desired product. 11 cl

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RU 2 114 854 C1

Authors

Lorens I.Berges

Gari R.Shul'Te

Dates

1998-07-10—Published

1993-09-17—Filed