FIELD: organic chemistry. SUBSTANCE: invention proposes new compounds of the general formula (I) 5-HT3 where 
and R1 are hydrogen or R2 and R1 form together bivalent radical: (a) -CH=CH-CH=C-; (b) -CH=C(Cl)-CH=CH- or (c) -CH= CH-C(Cl)=CH-; n = 2, 3 or 4; R2 - hydrogen or methoxy-group; m = 1 or 2; R3 - hydrogen, amino-group or R4-alkylcarbonylamino-group; C1-C3 - hydrogen or halogen, their stereochemical isomers and intermediate products of synthesis of the formula (XIXa) R5- and levorotatory isomer of the formula (Ia) (
). Invention proposes methods of synthesis of new compounds, pharmaceutical composition and an agent on the basis of compound of the general formula (I) that can be used in medicine for treatment of 5-R3= OCH3-mediated damages. EFFECT: improved method of synthesis of new compounds indicated above. 10 cl, 4 tbl
| Title |
Year |
Author |
Number |
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1993 |
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|
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