FIELD: organic chemistry. SUBSTANCE: products: derivatives of 1,3-substituted cycloalkene and cycloalkane of the formula (I) Z-CH2-Y where Z are compounds of the formulas 
and Y are compounds of the formulas 
where R - phenyl, 2-, 3- or 4-pyridinyl that can be substituted with lower alkyl, lower alkoxyl, 2-, 4- or5-pyrimidinyl, 2- or 3-thienyl, 3-indolyl, 2-, 3- or 4-quinolinyl; m = 1, 2 or 3. Reagent 1: compound of the formula (II) 
. Reagent 2: RM where R has value indicated above; M - magnesium or lithium halide. Reaction conditions: in the medium of solvent, for example, tetrahydrofuran, at 0 C followed by treatment the formed product with acid, for example, trifluoroacetic acid. Synthesized compounds are used in medicine as antipsychotic and antihypertension agents. EFFECT: improved method of synthesis. 8 cl, 2 tbl, 26 ex
| Title |
Year |
Author |
Number |
| METHOD OF SYNTHESIS OF R-(+)-1,2,3,6-TETRAHYDRO-4-PHENYL-1- -[(3-PHENYL-3-CYCLOHEXENE-1-YL)METHYL]PYRIDINE OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS, INTERMEDIATE SUBSTANCES AND METHODS OF THEIR SYNTHESIS |
1995 |
- Donal'D Judzhin Batler
- Dzhodett Dzhejlej
- Tang Van Li
- Viliem Dzhon Iii Smit
- Dejvid Jurgen Vjustro
|
RU2144026C1 |
| METHOD OF SYNTHESIS OF (S)-(-)- AND (R)-(+)-ISOMERS OF (5-AMINO-1,2-DIHYDRO-2-METHYL-3-PHENYLPYRIDO-[3,4-B]-PYRAZINE- -7-YL)-CARBAMIDE ACID ETHYL ESTER OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND INTERMEDIATE (S)-(-)- AND (R)-(+)-ISOMERS OF [6-AMINO-4-[[2-(ALKOXYALKYLAMINO)-1-METHYL-2-OXOETHYL]-AMI- -NO]-5-NITRO-2-PYRIDINYL]-CARBAMIDE ACID ETHYL ESTER |
1994 |
- Om Prakash Goehl[Us]
- Sham Shridkhar Nikam[In]
|
RU2098409C1 |
| SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINES, INTERMEDIATE COMPOUNDS AND PHARMCOMPOSITION |
1993 |
- Klifton Dzhon Blehnklej
- Dzhon Kuk Khodges
- Sil'Vester Klachko
|
RU2135473C1 |
| DERIVATIVES OF TETRAZOLE-CONTAINING AMIDE, A MIXTURE OF THEIR ISOMERS, SEPARATE ISOMERS OR PHARMACEUTICALLY ACCEPTABLE SALTS |
1992 |
- Pehtrik Majkl' O'Brajn
- Dzhozef Ehrmand Pikerd
- Klaud Forsi Perchiz
- Brus Dejvid Ros
- Dredzho Robert Sliskovich
- Ehndru Dejvid Uajt
|
RU2117664C1 |
| METHOD FOR PRODUCING SUBSTITUTED 6-ARYL-3(2A)-PYRIDAZINONES |
0 |
- Ila Sirkar
- Dzhejms Artur Bristol
|
SU1313346A3 |
| METHOD OF PRODUCING NAPHTHYRYDINE QUINOLINE- OR BENZOXAZINE CARBOLIC ACIDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OF ACID ADDITION |
0 |
- Taunli P.Kulbertson
- Dzhon M.Domagala
- Tomas F.Mich
- Dzheffri B.Nikols
|
SU1360584A3 |
| METHOD OF PRODUCING GUANINE DERIVATIVES, OR THEIR ACID-ADDITIVE PHARMACEUTICALLY ACCEPTABLE SALTS |
0 |
- Dzhegedish S.Sirkar
- Garri V.Pinter
|
SU1590044A3 |
| METHOD FOR PRODUCING QUINOLINECARBOXYLIC ACID DERIVATIVES OR ACID-ADDITIVE SALTS THEREOF |
0 |
- Taunli P.Kubertson
- Dzhon M.Domagala
- Tomas F.Mich
- Dzheffr B.Nikols
|
SU1314954A3 |
| METHOD OF PRODUCING PURIN DERIVATIVES |
0 |
- Dzhegedish S.Sirkar
- Garri V.Pinter.
|
SU1586514A3 |
| METHOD OF PRODUCING PYRIDAZINEAMINES OR PHARMACEUTICALLY ACCEPTABLE SALTS OF ACIDS THEREOF,OR STEREOCHEMICAL ISOMERS THEREOF,OR TAUTOMERS THEREOF |
0 |
- Rajmond Antuan Stokbroeks
- Marsel Jozef Mariya Van Der Aa
- Joannes Iozefus Mariya Villems
- Marsel Gerebernus Mariya Lyuiks
|
SU1384198A3 |
