DERIVATIVES OF TETRAZOLE-CONTAINING AMIDE, A MIXTURE OF THEIR ISOMERS, SEPARATE ISOMERS OR PHARMACEUTICALLY ACCEPTABLE SALTS Russian patent published in 1998 - IPC

FIELD: organic chemistry and technology. SUBSTANCE: product: derivatives of tetrazolo-containing amide of the general formula (I): where R₁ - phenyl possibly substituted with C_1-4-alkyl, C_1-3-alkoxyl, phenyl or fluorine; group of formula: where R₅ - C_1-3-alkyl; group of formula: where R₆ - C_1-4-alkyl; R₇ - 2-, 3- or 4-pyridyl; group of formula and where hydrocarbon with 1-18 C-atoms is saturated or unsaturated, C_3-8-cycloalkyl, 2-, 3- or 4-pyridyl possibly substituted with C_1-4-alkyl, 2-, 4- or 5-pyrimidinyl, and their N-oxides; R² and R³ - independently H, Hal, C_1-12-alkyl, C_3-8-cycloalkyl, phenyl, phenylalkyl possibly substituted at phenyl, C_2-6-alkenyl, 1- or 2-naphthyl; or they form together with C-atom C_1-4-alkylidene or C_3-7-spiroalkyl; R⁴ - C_1-20-hydrocarbon chain or C_1-20-alkylthio-group; n = 0, 1 or 2. Synthesized compounds show high activity as inhibitors of tranferase that acetylates cholesterol and low toxicity. EFFECT: improved method of synthesis, enhanced effectiveness, low toxicity. 31 cl, 14 dwg, 104 ex, 3 tbl