FIELD: organic chemistry and chemical technology. SUBSTANCE: invention describes the improved 5-stage method of synthesis of R-(+)-1,2,3,6-tetra-hydro-4-phenyl-1-[(3-phenyl-3-cyclohexene-1-yl)methyl] -pyridine from 5-oxo-3-phenyl-3-cyclohexene carboxylic acid. Except for, invention describes methods of separation of seteroisomers of 5-oxo-3-phenyl-3-cyclohexene carboxylic acid using cinchonidine for synthesis of (S)-5-oxo-3-phenyl-3- -cyclohexene carboxylic acid or using α-chymotrypsin for selective hydrolysis of 5-oxo-3-phenyl-3-cyclohexene carboxylic acid n-butyl ester to obtain (S)-5-oxo-3-phenyl-3-cyclohexene carboxylic acid. Invention describes also other valuable intermediate compounds used in proposed methods of synthesis. Method is useful for large-scale synthesis. EFFECT: improved method of synthesis, decreased cost of the parent reagents. 39 cl, 2 ex
| Title |
Year |
Author |
Number |
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