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Application

97102130/04, 1997-02-13

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Actual filing date

1997-02-13

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Published

1998-07-27

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Inventor

Mikhajlitsyn F.S.Kovalenko F.P.Kozyreva N.P.Dzhabarova V.I.Lebedeva M.N.Mynzhanov M.R.Lychko N.D.Bulanova T.E.

(73)

Holder

Institut Meditsinskoj Parazitologii I Tropicheskoj Meditsiny Im.E.I.Martsinovskogo

4-[(BENZO-2,1,3-THIADIAZOLYL-4)-AMINO]-5,6,7,8-TETRAHYDROBEN-ZOTHIENO-[2,3-D]-PYRIMIDINE SHOWING ANTHELMINTIC ACTIVITY IN LARVAL ALVEOLAR ECHINOCOCCOSIS Russian patent published in 1998 - IPC

Abstract RU 2116309 C1

FIELD: organic chemistry. SUBSTANCE: invention proposes new heterocyclic compound, - 4-[(benzo-2,1,3-thiadiazolyl-4)-amino] -5,6,7,8-tetrahydroben-zothieno-[2,3-d] -pyrimidine showing the improved anthelmintic activity. Compound provides an effective inhibition of growth of larvocysts of alveolar echinococcus (by 90.8%) and death of the most part of parasitic larvocysts (by 70-90%) in infected cotton rats in experiment as compared with the known antiechinococcosis preparation mebendazol. The proposed compound shows low toxicity and tolerated by mice at the dose 4.0 g/kg without any toxic symptoms. EFFECT: enhanced effectiveness of new compound indicated above. 1 tbl

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RU 2 116 309 C1

Authors

Mikhajlitsyn F.S.

Kovalenko F.P.

Kozyreva N.P.

Dzhabarova V.I.

Lebedeva M.N.

Mynzhanov M.R.

Lychko N.D.

Bulanova T.E.

Dates

1998-07-27—Published

1997-02-13—Filed

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