DERIVATIVES OF 1-(ARYLALKYLAMINOALKYL)-IMIDAZOLE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND A METHOD OF TREATMENT Russian patent published in 1998 - IPC

FIELD: organic chemistry and chemical technology. SUBSTANCE: invention relates to imidazole derivatives of the formula (I) and their pharmaceutically acceptable salts where R₁, R₂ and R₃ mean independently hydrogen, halogen, alkoxy, phenoxy, phenyl, alkoxycarbonyl, -NR₁₃R₁₄, halogenated alkoxy, halogenated alkyl, benzylhydroxy, hydroxy, hydroxyalkyl, (C_2-6-alkoxycarbonyl)-vinyl, S(O)_nR⁷, carbamoylalkyl, alkoxycarbonylalkyl, -CONR₁₁R₁₂, or R₁ and R₂ together with phenyl ring mean independently hydrogen, alkyl, phenyl, or together with carbon atom they presents C_3-6-cycloalkyl; R₆ means hydrogen, alkyl or ω - -hydroxyalkyl; A means C_2-5-alkylene; R₈ means hydrogen, alkyl, halogen, alkoxy, hydroxyalkyl, benzyl or phenyl; R₉ and R₁₀ mean independently hydrogen, alkyl, halogen, alkoxy, phenyl, hydroxyalkyl, alkoxycarbonyl, nitro, NR₃₀R₃₁, alkanoylhydroxyalkyl or aminomethyl. Synthesized compounds show antiallergic and antiinflammatory properties. Invention describes compositions containing these compounds and methods of their synthesis. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 16 cl, 18 tbl, 109 ex