2,3,4,5-TETRAHYDRO-1,4-BENZOTHIAZEPINES, STEREOISOMERS THEREOF OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION HAVING ANTICONVULSIVE EFFECT Russian patent published in 1998 - IPC

FIELD: chemistry of heterocyclic compounds. SUBSTANCE: present invention describes 2,3,4,5-tetrahydro -1,4, -benzothiazepines of formula II: wherein n is 0 or 1; R₁,R₂,R₆ and R₇ are H; R₃ and R₄ are H or methyl, or together are imino, methylimino, phenylimino, hydoxyimino or methoxyimino group; R₅ is H or methyl, or when R₃ and R₄ are H or methyl, R₅ is H, methyl, formyl, acetyl, propionyl, benzoyl, methyl, sulfinyl, methyl sulfonyl or ethyl sulfonyl; R₈ is H, methyl, fluorine or chlorine; and R₉,R₁₀ and R₁₁ are H provided that R₁-R₁₁ are not all H, and when n is O and R₁-R₄ and R₆-R₁₁ are H, then R₅ is not benzoyl or acetyl, and when n is O or 1 and R₄ is methyl, then R₁-R₃ and R₅-R₁₁ are not all hydrogen, stereoisomers thereof or pharmaceutically acceptable salts thereof. The claimed method of preparing compounds of formula II comprises reducing corresponding 2,3,4,5- tetrahydro -1,4-benzothiazepine 3-oxo derivatives. The pharmaceutical composition has anticonvulsive effect and comprises, as active ingredient, compounds of formula II or identical 2,3,4,5-tetrahydro-1,4- benzothiazepine derivatives. EFFECT: improved properties of the pharmaceutical composition. 13 cl, 31 ex