FIELD: medicine, oncology. SUBSTANCE: conjugate of antimelanoma antibody and cytotoxic agent is a conjugate of monoclonal antibody ZME-018 to an antigen GP-240 of melanoma cancer cells. Conjugate has also toxins or cytocidal agents, or cytostatics as cytotoxic agent. Method of melanoma inhibition involves administration to mammal with melanoma a conjugate by parenteral route at the dose 0.1-10 mg/1 kg body mass. EFFECT: enhanced effectiveness of melanoma inhibition. 4 cl, 13 dwg, 1 tbl
Authors
Dates
1998-09-27—Published
1991-04-19—Filed