METHOD OF SYNTHESIS OF SUBSTITUTED 1,10-PHENANTHROLINES Russian patent published in 1998 - IPC

FIELD: organic chemistry and chemical technology. SUBSTANCE: invention relates to a method of synthesis of substituted phenanthrolines of the general formula (I) where R₁ means ethyl, isopropyl, n-butyl; R₂ means phenyl, propyl, isobutyl, pentyl; R₃ means propyl, isobutyl, pentyl, hydrogen atom; R₄ means ethyl, isopropyl, n-butyl, hydrogen atom. Method of synthesis involves interaction of o-phenylenediamine or 8-aminoquinoline with the corresponding aliphatic aldehydes or the corresponding aliphatic or aromatic aldehydes at mole ratio = 1:(2-4), at 140-160 C for 6-8 h in the presence of catalyst containing praseodymium trichloride, organophosphorus compound (PR₃) and dimethylformamide at mole ratio = (0.5-1): (2-4): (4-15). The yield of the end products is 50-80%. The synthesized compounds can be used in analytical chemistry and as semiproducts for synthesis of compounds showing pharmacological and pesticide activity. EFFECT: increased yield of the end compounds. 1 tbl, 7 ex