6-[X-(2-HYDROXYETHYL)AMINOALKYL]-5,11-DIOXO-5,6-DIHYDRO- 11H-INDENO [1,2-C]ISOQUINOLINES OR SALTS THEREOF WITH INORGANIC AND ORGANIC ACIDS, METHODS OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION BASED THEREON Russian patent published in 1998 - IPC

Abstract RU 2120939 C1

FIELD: medicine. SUBSTANCE: invention describes indeno [1,2-c]isoquinoline derivatives of formula I wherein X is the number of carbon atoms of 0-5 in aminoalkyl group. Indenoisoquinolines are prepared by reacting indeno [1,2-c] isocumarine and/or 1-methoxy-2- (2-methoxycabonylphenyl)-inden-3-one with N- (hydroxyethyl)alkylene diamine in aprotic solvent at elevated temperature. The other preparation method comprises reacting 6-(X-chloroalkyl)-5,11-dioxo-5,6- dihydro-11H-indeno [1,2-c] isoquinolines with 2- aminoethanol in the presence of anhydrous potassium carbonate in suitable solvent. Compounds of formula i have antitumor activity and are useful for preparation of agents for treating malignant tumors in mammals. EFFECT: improved properties of the pharmaceutical composition. 7 cl, 17 ex, 6 tbl

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RU 2 120 939 C1

Authors

Jirzhi Mikhalsky

Jirzhi Grbata

Jirzhi Krzhepelka

Milan Melka

Milan Miko

Milan Gruby

Milan Ferents

Eva Skatselova

Irena Kejgova

Ruzhena Rajkhlova

Anna Kargerova

Jitka Shediva

Alois Kolonichny

Jozef Urbanets

Dates

1998-10-27Published

1992-08-27Filed