FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new 8-fluoroanthracyclines of the formula (I) 
where R is H; R1 is H, OCH3; R2 is H, NH2; R3 is OH, NH2; symbol 
means that substituents R2, R3 can be in axis or equatorial configuration and groups 8-F and 9-OH are at cis-position; or their pharmaceutically acceptable salts. They show the extremely high antitumor activity. Invention describes the method of synthesis of claimed compounds and pharmaceutical compositions containing thereof also. EFFECT: improved method of synthesis, high antitumor activity. 6 cl, 1 dwg, 1 tbl, 7 ex
| Title |
Year |
Author |
Number |
| ANTRACYCLINIC DISACCHARIDES, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF |
1994 |
- Fabio Animati
- Paolo Lombardi
- Federiko Arkamone
- Amalija Chipollone
|
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- Fabio Animati[It]
- Paolo Lombardi[It]
- Federiko Arkamone[It]
|
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1990 |
- Alessandro Dzholitti[It]
- Antonio Gvidi[It]
- Franko Paskvi[It]
- Vittorio Pestellini[It]
- Federiko Arkamone[It]
|
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| DERIVATIVES OF PENEM, THEIR SYNTHESIS AND A PHARMACEUTICAL COMPOSITION CONTAINING SAID AND SHOWING ANTIBACTERIAL ACTIVITY |
1993 |
- Marija Al'Tamura
- Federiko Marija Arkamone
- Ehntso Perrotta
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- P'Ero Sbrachi
- Dzhuzeppe Kasch'O
|
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1996 |
- Pol M. Skola
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|
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| 3-SUBSTITUTED OXINDOLE DERIVATIVES AS MODULATORS OF POTASSIUM CHANNELS, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT |
1996 |
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|
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| SIDE CHAIN TAXANES, INTERMEDIATE COMPOUNDS, AND METHODS OR PREPARING, THEREOF |
1993 |
- Mikaehl A.Poss
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|
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|
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| ANTHRACYCLINE GLYCOSIDE AND METHOD OF ITS SYNTHESIS |
1992 |
- Antonio Suarato[It]
- Franchesko Andzheluchchi[It]
- Al'Berto Bardzhotti[It]
- Marija Grandi[It]
- Gabriehlla Petstsoni[It]
|
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| SULFAMIDE COMPOUNDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND METHOD OF INHIBITION OF ET RECEPTORS |
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|
RU2141953C1 |
