SUBSTITUTED DERIVATIVES OF INDENO[1,2-c]ISOQUINOLINE, COMPOSITIONS AND TREATMENT METHODS BASED ON THEREOF Russian patent published in 2007 - IPC C07D211/18 A61K31/435 A61P29/00 A61P37/06 A61P3/10 

FIELD: chemistry of heterocyclic compounds, organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes compound of the formula (Ib): or pharmaceutically acceptable hydrate of salt of indicated compound wherein R₅ means oxygen atom (O); R₆ means hydrogen atom (H); X means -CH₂-, -CH(OH)(CH₂)_n- or -CH(NR₁₁R₁₂)- wherein n = 0; R₁₁ and R₁₂ mean independently hydrogen atom or (C₁-C₉)-alkyl or nitrogen atom (N), either R₁₁ and R₁₂ taken in common form 5-10-membered aromatic or nonaromatic carbocycle wherein 1-4 carbon atoms in ring are replaced independently with N, O or sulfur (S) atom and wherein at least of them represents nitrogen atom; R₁, R₂, R₃, R₄, R₇, R₈, R₉ and R₁₀ mean independently hydrogen atom or -A-B wherein A means -SO₂-; B means -NZ₁Z₂, 5-10-membered aromatic or nonaromatic carbocycle wherein 1-4 carbon atoms in ring are replaced independently with N, O or S and wherein any of these atoms is unsubstituted or substituted with one or more groups comprising (C₁-C₁₀)-alkyl, (C₁-C₅)-alkylene-OC(O)-(C₁-C₅)-alkyl; Z₁ and Z₂ mean independently H or (C₁-C₁₀)-alkyl that is unsubstituted or substituted with one or more groups -N(Z₃)(Z₄) wherein Z and Z₄ mean independently H or (C₁-C₅)-alkyl that is unsubstituted or substituted with one or more hydroxy-groups; either N, Z₃ and Z₄ taken in common form unsubstituted or substituted 5-10-membered aromatic or nonaromatic carbocycle wherein 1-4 carbon atoms in ring are replaced independently with N, O or S and wherein one of these atoms represents nitrogen atom.

EFFECT: valuable medicinal properties of compounds.

42 cl, 4 tbl, 2 ex