1-OXA-3-AZADIBENZOAZULENES AS INHIBITORS OF PRODUCING TUMOR NECROSIS FACTOR AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING Russian patent published in 2008 - IPC C07D498/04 A61K31/424 A61K31/38 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel compounds of the formula (I): , wherein X represents heteroatom, such as oxygen (O) or sulfur (S) atoms; X and Z mean independently of one another one or some identical or different substitutes bound any available carbon atom and they can represent hydrogen atom or halogen atom; R¹ represents a substitute of the formula (II): , wherein R² and R³ can represent simultaneously or independently of one another hydrogen atom or (C₁-C₄)-alkyl, or R¹ can represent hydrogen, halogen atom, (C₁-C₇)-alkyl, -CHO, -(CH₂)₂COOH, -(CH₂)₂CO₂Et, (CH₂)_mL wherein L means -OH or bromine atom (Br); m represents a whole number from 1 to 3; n represents a whole number from 0 to 3; Q₁ and Q₂ represent independently of one another oxygen atom or group of the formula: wherein substitutes y₁ and y₂ represent hydrogen atom, and to their pharmacologically acceptable salts. Also, invention relates to use of these compounds as intermediate substances used in synthesis of novel compounds of dibenzoazulene class, and to their using for preparing drugs.

EFFECT: valuable medicinal properties of compounds.

9 cl, 4 tbl, 13 ex