FIELD: organic chemistry, medicine, pharmacology. SUBSTANCE: invention proposes a compound of the formula (I) for new application where n = 0 or 1; R is hydroxy-group, methoxy-group, (C1-C7)-alkanoylhydroxy-group, (C3-C7)-cycloalkanoyl- -hydroxy-group, (C1-C6)-alkoxy-(C1-C7)-alkanoylhydroxy-group, free or substituted aroylhydroxy-group or free or substituted aroyl- -carboxy-group; R1 is hydrogen atom, hydroxy-group, halogen atom, methoxy-group, (C1-C7)-alkanoylhydroxy-group, (C3-C7)-cycloalka- -noylhydroxy-group, (C1-C6)-alkoxy-(C1-C7)-alkanoylhydroxy-group, free or substituted aroylhydroxy-group or free or substituted aroylcarboxy-group; R2 is heterocyclic ring taken from the group involving pyrrolidine, piperidine or hexamethyleneimine group, or its pharmaceutically acceptable salt or solvate used for decrease of blood cholesterol content. Invention proposes a pharmaceutical composition for the same aim based on compound of the general formula (I). EFFECT: broadened pattern of hypocholesterolemic agents. 5 cl, 7 tbl
Authors
Dates
1998-12-20—Published
1993-12-13—Filed