DERIVATIVES OF DECAPEPTIDES AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF Russian patent published in 1998 - IPC

FIELD: chemistry of peptides. SUBSTANCE: invention relates to decapeptides of the formula (I): X-X₁-X₂-X₃-Ser-Tyr--X₆=-Leu--X₈-Pro-X₁₀ where X - acyl; X₁ is D-Nal; X₂ is D-Cpa; X₃ is D-Pal; X₆ is D-Cit, D-Hei, D-Orn, D-Lys, D-Neu; X₈ is Orn, Arg, Lys, L-Neu; X₁₀ is D-Ala-NH₂; Neu is a residue of the formula (IX) or (IV) ; Z - a group -O- or -S-; n = 1-6. Pharmaceutical composition shows LHRH-antagonistic activity. Synthesized compounds of the formula (I) show very high pharmacological activity in combination with low level of histamine release. EFFECT: enhanced activity, low adverse effect. 6 cl, 22 ex