DERIVATIVES OF PYRIDO[1,2,3-DE]QUINOXALINE, METHODS OF THEIR SYNTHESIS, DRUG Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new derivatives of pyrido[1,2,3-de] -quinoxaline of the general formula (I) where R′,R² and R³ each means hydrogen atom, -POXY, halogen atom or -COR; R⁴,R⁵ mean hydrogen atom; R⁶ and R⁷ are similar or distinct and mean hydrogen, halogen atoms, nitro-, cyano-group, CF₃ or NR¹²R¹³ or R⁵ and R⁶ or R⁶ and R⁷ mean near-condensed benzene ring; X and Y are similar and mean hydroxyl or C₁-C₆-alkoxyl; R means hydroxyl or C₁-C₆-alkoxyl; R¹² and R¹³ mean hydrogen atom or in common with nitrogen atom form piperidyl-, morpholyl-, 1,2,4-triazolyl-, imidazolyl- or pyrrolyl-group or their salts. New compounds can be used as drugs for treatment of patients with diseases of central nervous system for counteraction of hyperactivity of exciting amino acids. Invention describes also a method of their synthesis and a drug based on compounds of the formula (I). EFFECT: improved methods of synthesis, valuable pharmacological activity. 5 cl, 10 ex