DERIVATIVES OF PHENOXY- OR PHENOXYALKYLPIPERIDINE AND ANTIVIRAL COMPOSITION BASED ON THEREOF Russian patent published in 1999 - IPC

Abstract RU 2125565 C1

FIELD: organic chemistry, virology. SUBSTANCE: invention relates to new derivatives of phenoxy- or phenoxyalkylpiperidine of the formula (I) where R₁- are or and R₄- are or ; R₂ and R₃ - hydrogen, lower alkyl or halogen; R₅ and R₆ - hydrogen, lower alkyl, halogen; R₇ - hydrogen or lower alkyl; R₈ - hydrogen, lower alkyl, trifluoromethyl; R₉ - lower alkyl; R₁₀ - lower alkyl, difluoromethyl, trifluoromethyl; Y - a covalent bond, lower alkylene, or their salts. Invention relates to also an antiviral composition based on compounds of the formula (I) taken at effective doses that can be used in medicine for treatment and prophylaxis of patients with viral infection. Compounds of the formula (I) are synthesized by interaction of (I)-R₁-4-hydroxy-, (I)-R₁-4-hydroxyalkylpiperidine of the formula (II) with phenol of the formula (III) in the presence of triphenylphosphine and diethylazo- -dicarboxylate in inert solvent. EFFECT: improved method of synthesis. 9 cl, 3 tbl, 17 ex

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RU 2 125 565 C1

Authors

Gaj Dominik Diana

Dates

1999-01-27—Published

1993-12-23—Filed